The behavioural and neural effects of cannabinoids: Studies using Lewis and Wistar strain rats
نویسنده
چکیده
XI Abbreviations XVIII Publications and Submissions XX Chapter 1 Cannabis: a review of use, abuse and dependence 1 1.1. A brief history of cannabis use 1 1.2. Current use of cannabis 4 1.3. Recent advances in cannabinoid science 7 1.4. Cannabis dependence in humans 11 1.5. Why do people become dependent on cannabis? 15 1.5.1. The cannabis withdrawal syndrome 16 1.5.2. The role of cannabis withdrawal in maintaining cannabis dependence 18 1.5.3. Cannabis withdrawal in laboratory animals 18 1.5.4. Animal models of cannabinoid self-administration 21 1.5.5. Cannabinoid self-administration in mice? Evidence and limitations 25 1.5.6. Cannabinoid effects on the mesolimbic DA system 27 1.6. Genetic basis of cannabinoid euphoria and dysphoria: the Lewis strain of rat 29 1.7. " Gateway " effects of cannabis: the cross-sensitization phenomenon 32 1.8. The role of the endogenous cannabinoid system in reward 36 1.9. Aims of the current thesis 37
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